The effect of survivin gene in breast cancer risk and prognosis

Abstract Objectives The accumulation of genetic damages in onset cancer induce activation protooncogenes or inactivation tumor suppressor genes thus cause disruption the balance between cell proliferation and programmed death. As a member apoptosis inhibitory protein family (IAP), survivin play important roles carcinogenesis process. evidence suggests that polymorphisms located promoter region may be determining susceptibility cancer. In this study, we aimed to examine possible role −31 −625 G/C gene breast Methods A total 160 cases 153 healthy controls were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methodology. Results Genotype allele distributions not significantly different two groups. However, observed carriers C/G homozygous genotypes (GG/CC) higher patients with necrosis (p=0.047). Conclusions Our results suggest related prognosis, but are opinion our result require validated larger samples further comprehensive research explore correlation.